The Role of Prognostic variables in the Maturation of ovarian Cancer

Abstract

Background. Ovarian cancer is the leading cause of death of all gynecological tumors. Most often, ovarian
cancer arises from the epithelial layer of the ovary. Most of the cases are identified in highly developed
stages.
Methodology.Fifty previously diagnosed patients with ovarian cancer were considered and the venous
blood samples of 5 mL were taken, following their informed consent.Fifty healthy women of the same age
were regarded as a control group, and blood samples were obtained following their consent. The collected
samples were analyzed for the following biomarkers: Malondialdehyde (MDA), Superoxide Dismutase
(SOD), Glutathione (GSH), Catalase (CAT), Interleukin-2 (IL-2), Tumor Necrosis Factor-alpha (TNF-α), Matrix
Metalloproteinase-9 (MMP-9), and Nitric Oxide (NO).
Results. Serum levels of ovarian cancer patients regarding MDA, TNF-α, MPP-9, and NO were significantly
raised as compared to the control. However, the levels of SOD, GSH, and CAT was significantly low.
Conclusion. Highlevels of MDA, TNF-α, MMP-9, and NO, whereas low levels of GSH, CAT, and SOD can be
used as an early predictor of ovarian cancer.