EFFECT OF NICOTINIC ACID ON TRIACYLGLYCEROL LEVELS IN DIABETIC AND NON-DIABETIC RATS

Abstract

Back Ground: Determination of nicotinic acid effectiveness on serum triacylglycerol levels in diabeticandnon-
diabeticrats
Methods: It was an experimental study conducted at the Institute of Molecular Biology and Biotechnology
at the University of Lahore, Pakistan. Nicotine acid was given for a total of 42 days to diabetic and non-
diabetic albino rats and a treatment response was registered on day 21 and on day 42 of the experiment.
The analysis of variance (Anova) was used to compare these two groups and the control groups. P value of
(p < 0.05) was considered as significant. The research included a total of 50 rats.
Results: In comparison with control groups, serum levels of triacylglycerol (TAG) decreased significantly
with nicotinic acid in the dyslipidemic group and the dyslipidemic + diabetic group on 21st and the day 42.
Conclusion: The nicotinic acid is an effective agent in lowering the TAGdyslipidemiain diabetic and
nondiabetic rats.`